蔡华清-中国科学院大学-UCAS
[中文]
[English]
招生信息
教育背景
工作经历
出版信息
科研活动
基本信息
蔡华清 女 生物物理研究所 电子邮件：huaqingcai@ibp.ac.cn 通信地址：北京市朝阳区柳芳南里11号楼804 邮政编码：
研究领域
细胞趋化的分子机理与调控机制
通过基因和信号转导网络感应环境变化并作出正确应答是细胞的重要功能。趋化现象（定向细胞迁移）是细胞感应外界信号分子空间梯度的生动表现，它由细胞的运动、极性和方向感应三个相互关联的模块组成。细胞的定向运动在胚胎发育中的器官形成及神经元布线、损伤修复和干细胞归巢等诸多生物过程中起关键作用，同时也是炎症反应和癌症转移发生的重要环节。利用细胞生物学、生物化学、光遗传及化学遗传学等多种手段，结合经典模式生物盘基网柄菌（Dictyostelium discoideum）和动物细胞模型，本课题组致力于研究趋化相关的基因和信号转导网络，揭示它们的结构设计在单细胞和群体水平的作用原理及其在定向运动行为中的重要功能，以期阐明包括癌细胞转移等复杂生物学过程的分子机理。
招生信息
招生专业
071009-细胞生物学
招生方向
细胞趋化及癌细胞转移的分子机理
教育背景
2001-09--2007-05 美国耶鲁大学 理学博士 1997-09--2001-07 北京大学 理学学士
工作经历
工作简历
2015-09~现在, 中科院生物物理所, 研究组长2013-07~2015-08,美国约翰霍普金斯大学, 研究助理2007-10~2013-07,美国约翰霍普金斯大学, 博士后
出版信息
发表论文
[1] Dong Li, Feifei Sun, Yihong Yang, Hui Tu, Huaqing Cai. Gradients of PI(4,5)P2 and PI(3,5)P2 jointly participate in shaping the back state of Dictyostelium cells. Frontiers in Cell and Developmental Biology[J]. 2022, 835185-, [2] Yiwei Zhang, Hui Tu, Yazhou Hao, Dong Li, Yihong Yang, Ye Yuan, Zhonglong Guo, Lei Li, Haibin Wang, Huaqing Cai. Oligopeptide transporter Slc15A modulates macropinocytosis in Dictyostelium by maintaining intracellular nutrient status. JOURNAL OF CELL SCIENCE[J]. 2022, 135(7):&nbspjcs259450-, [3] Hui Tu, Zhimeng Wang, Ye Yuan, Xilin Miao, Dong Li, Hu Guo, Yihong Yang, Huaqing Cai. The PripA-TbcrA complex-centered Rab GAP cascade facilitates macropinosome maturation in Dictyostelium. Nature Communications[J]. 2022, 13(1):&nbsp1-15, [4] Yang, Yihong, Li, Dong, Chao, Xiaoting, Singh, Shashi P, Thomason, Peter, Yan, Yonghong, Dong, Mengqiu, Li, Lei, Insall, Robert H, Cai, Huaqing. Leep1 interacts with PIP3 and the Scar/WAVE complex to regulate cell migration and macropinocytosis. JOURNAL OF CELL BIOLOGY[J]. 2021, 220(7):&nbsphttp://dx.doi.org/10.1083/jcb.202010096.[5] Zhan, Huiwang, Bhattacharya, Sayak, Cai, Huaqing, Iglesias, Pablo A, Huang, ChuanHsiang, Devreotes, Peter N. An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. DEVELOPMENTAL CELL[J]. 2020, 54(5):&nbsp608-+, http://dx.doi.org/10.1016/j.devcel.2020.08.001.[6] Jiao, Zhihua, Cai, Huaqing, Long, Yu, Sirka, Orit Katarina, Padmanaban, Veena, Ewald, Andrew J, Devreotes, Peter N. Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(8):&nbsp4158-4168, https://www.webofscience.com/wos/woscc/full-record/WOS:000516771500041.[7] Zhuang, Yan, Zuo, Daqing, Tao, Yihan, Cai, Huaqing, Li, Lei. Laccase3-based extracellular domain provides possible positional information for directing Casparian strip formation in Arabidopsis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(27):&nbsp15400-15402, https://www.webofscience.com/wos/woscc/full-record/WOS:000548351700008.[8] Edwards, Marc, Cai, Huaqing, AbubakerSharif, Bedri, Long, Yu, Lampert, Thomas J, Devreotes, Peter N. Insight from the maximal activation of the signal transduction excitable network in Dictyostelium discoideum. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(16):&nbspE3722-E3730, https://www.webofscience.com/wos/woscc/full-record/WOS:000430191900017.[9] Miao, Yuchuan, Bhattacharya, Sayak, Edwards, Marc, Cai, Huaqing, Inoue, Takanari, Iglesias, Pablo A, Devreotes, Peter N. Altering the threshold of an excitable signal transduction network changes cell migratory modes. NATURE CELL BIOLOGY[J]. 2017, 19(4):&nbsp329-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000397917000011.[10] Senoo, Hiroshi, Cai, Huaqing, Wang, Yu, Sesaki, Hiromi, Iijima, Miho. The novel RacE-binding protein GflB sharpens Ras activity at the leading edge of migrating cells. MOLECULAR BIOLOGY OF THE CELL[J]. 2016, 27(10):&nbsp1596-1605, https://www.webofscience.com/wos/woscc/full-record/WOS:000376456800006.[11] Ding, Jingzhen, Segarra, Veronica A, Chen, Shuliang, Cai, Huaqing, Lemmon, Sandra K, FerroNovick, Susan. Auxilin facilitates membrane traffic in the early secretory pathway. MOLECULAR BIOLOGY OF THE CELL[J]. 2016, 27(1):&nbsp127-136, https://www.webofscience.com/wos/woscc/full-record/WOS:000367256400011.[12] Hoeller, Oliver, Toettcher, Jared E, Cai, Huaqing, Sun, Yaohui, Huang, ChuanHsiang, Freyre, Mariel, Zhao, Min, Devreotes, Peter N, Weiner, Orion D. G beta Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration. PLOS BIOLOGY[J]. 2016, 14(2):&nbsphttps://www.webofscience.com/wos/woscc/full-record/WOS:000371883600012.[13] Santhanam, Balaji, Cai, Huaqing, Devreotes, Peter N, Shaulsky, Gad, KatohKurasawa, Mariko. The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium. NATURE COMMUNICATIONS[J]. 2015, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000358853600004.[14] Cai, Huaqing, KatohKurasawa, Mariko, Muramoto, Tetsuya, Santhanam, Balaji, Long, Yu, Li, Lei, Ueda, Masahiro, Iglesias, Pablo A, Shaulsky, Gad, Devreotes, Peter N. Nucleocytoplasmic Shuttling of a GATA Transcription Factor Functions as a Development Timer. SCIENCE[J]. 2014, 343(6177):&nbsp1329-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000333108500029.[15] Huaqing Cai, Peter N. Devreotes. Moving in the right direction: How eukaryotic cells migrate along chemical gradients. Seminars in Cell and Developmental Biology. 2011, 22(8):&nbsp834-841, http://dx.doi.org/10.1016/j.semcdb.2011.07.020.[16] Cai, Huaqing, Das, Satarupa, Kamimura, Yoichiro, Long, Yu, Parent, Carole A, Devreotes, Peter N. Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis. JOURNAL OF CELL BIOLOGY[J]. 2010, 190(2):&nbsp233-245, https://www.webofscience.com/wos/woscc/full-record/WOS:000280593300009.[17] 蔡华清. TRAPPI tethers COPII vesicles by binding the coat subunit Sec23p. Nature. 2007, [18] Cai, Huaqing, Reinisch, Karin, FerroNovick, Susan. Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. DEVELOPMENTAL CELLnull. 2007, 12(5):&nbsp671-682, http://dx.doi.org/10.1016/j.devcel.2007.04.005.[19] Cai Huaqing, Zhang Yueyi, Pypaert Marc, Walker Lee, Ferro-Novick Susan. Mutants in trs120 disrupt traffic from the early endosome to the late Golgi. The Journal of Cell Biology. 171(5):&nbsp823-833, https://www.webofscience.com/wos/woscc/full-record/WOS:000233753700009.
科研活动
科研项目
（ 1 ）&nbsp中组部第十二批****青年人才项目, 主持, 国家级, 2016-01--2018-12（ 2 ）&nbsp生物膜相关蛋白质机器的动态变化、结构与功能, 参与, 国家级, 2016-06--2021-05
2013 中国科学院大学，网络信息中心.